InterPAD - DETAILS

3beta,6alpha,16beta,20R,24S; astragaloside IV of astragaloside A, astragaloside A, astragaloside IV, astragaloside-A, astramembrannin I, cyclosiversioside F

No.	Title	Href
1	Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway. Biochem Cell Biol. 2021 Apr;99(2):214-222. doi: 10.1139/bcb-2020-0026.	`Click`
2	Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy. Drug Dev Res. 2022 Apr;83(2):461-469. doi: 10.1002/ddr.21878.	`Click`

No.

Title

Href

Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway. Biochem Cell Biol. 2021 Apr;99(2):214-222. doi: 10.1139/bcb-2020-0026.

Click

Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy. Drug Dev Res. 2022 Apr;83(2):461-469. doi: 10.1002/ddr.21878.

Click

Name	Astragaloside IV
PubChem CID	13943297
Molecular Weight	785.0g/mol
Synonyms	3beta,6alpha,16beta,20R,24S; astragaloside IV of astragaloside A, astragaloside A, astragaloside IV, astragaloside-A, astramembrannin I, cyclosiversioside F
Formula	C₄₁H₆₈O₁₄
SMILES	CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(CO8)O)O)O)C
InChI	1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
InChIKey	QMNWISYXSJWHRY-YLNUDOOFSA-N
CAS Number	84687-43-4
ChEMBL ID	CHEMBL3121562
ChEBI ID	CHEBI:65457
KEGG ID	C17799
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	HuangQi
Use Part	Root
Habitat	NeiMengGu, ShanXi, GanSu, HeiLongJiang
Flavor	Sweet
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Astragalus 　　　　　　-->Species: Astragalus membranaceus

Chineses Pinyin	ZhiHuangQi
Use Part	Root Of Prepared Manyinflorescenced Sweetvetch Root
Habitat	NeiMengGu, ShanXi, HeiLongJiang
Flavor	Sweet
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Astragalus 　　　　　　-->Species: Astragalus membranaceus

Chineses Pinyin	DangGui
Use Part	Root
Habitat	SiChuan, YunNan, Shaanxi, GuiZhou, QingHai, NingXia
Flavor	Sweet, Pungent
Meridian Tropism	Liver, Heart, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Angelica 　　　　　　-->Species: Astragalus membranaceus

Chineses Pinyin	MengGuHuangQi
Use Part	Root
Habitat	HeiLongJiang, JiLin, NeiMengGu, HeBei, ShanXi, XiZang
Flavor	Sweet
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Astragalus 　　　　　　-->Species: Astragalus membranaceus

Pair Name	Astragaloside IV, Carboplatin
Partner Name	Carboplatin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	NFKB1	hsa4790
	Up-regulation	Phosphorylation	NFKBIA	hsa4792
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	RELA	hsa5970
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
In Vivo Model	AgIV synergized with carboplatin to suppress tumor xenograft growth of PC-3 cells, and decreased pAKT and p-p65 levels in vivo.
Result	Our results suggested that AgIV enhanced carboplatin sensitivity in prostate cancer cell lines by suppressing AKT/NF-κB signaling, thus suppressed epithelial-mesenchymal transition induced by carboplatin. Our findings provided a new mechanism for AgIV in overcoming drug resistance of platinum-based chemotherapy and suggested a potential combination therapy of AgIV and carboplatin in prostate cancer.

Pair Name	Astragaloside IV, Bevacizumab
Partner Name	Bevacizumab
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BECN1	hsa8678
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	This paper demonstrates that AST-IV enhances the effect of BV on inhibiting proliferation and promoting apoptosis of lung adenocarcinoma cells through inhibiting autophagy pathway.